Mechanistic Studies on Activation of Ubiquitin and Di-ubiquitin-like Protein, FAT10, by Ubiquitin-like Modifier Activating Enzyme 6, Uba6

Conjugation of the Ubiquitin Activating Enzyme UBE1 with the Ubiquitin-Like Modifier FAT10 Targets It for Proteasomal Degradation

The ubiquitin-like modifier HLA-F adjacent transcript 10 (FAT10) directly targets its substrates for proteasomal degradation by becoming covalently attached via its C-terminal diglycine motif to internal lysine residues of its substrate proteins. The conjugation machinery consists of the bispecific E1 activating enzyme Ubiquitin-like modifier activating enzyme 6 (UBA6), the likewise bispecific ...

Functional analysis of the ubiquitin-like modifier FAT10 in autophagy

The Ubiquitin-like modifier FAT10 in tolerance induction

III I have made the most important discovery of my career, the most important discovery of my life. It is only in the mysterious equations of love that any logic or reasons can be found. cited from " A beautiful mind " IV Acknowledgement I would like to express my gratitude to Marcus Groettrup for taking me back with open arms in the lab after failure of the " French adventure " , his constant ...

The Ubiquitin-Like Protein FAT10 Mediates NF- B Activation

NFB is a central mediator of innate immunity and contributes to the pathogenesis of several renal diseases. FAT10 is a TNF–inducible ubiquitin-like protein with a putative role in immune response, but whether FAT10 participates in TNF–induced NFB activation is unknown. Here, using renal tubular epithelial cells (RTECs) derived from FAT10 / and FAT10 / mice, we observed that FAT10 deficiency abr...

SUMO: a ubiquitin-like protein modifier.

SUMO (Small Ubiquitin-related Modifier) is a small protein that covalently attaches to a lysine residue of another protein in a reversible fashion. SUMO attachment to its substrate proteins causes changes in the localization, activity, or binding partners of the substrate. SUMO has been shown to play a role in a multitude of processes; these include chromosome segregation, cell cycle progressio...